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Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.
Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X, Huang B, Xu X, Zheng J, Cao X. Liu Y, et al. Cancer Cell. 2016 Aug 8;30(2):243-256. doi: 10.1016/j.ccell.2016.06.021. Cancer Cell. 2016. PMID: 27505671 Free article.
Here, we demonstrate that lung epithelial cells are critical for initiating neutrophil recruitment and lung metastatic niche formation by sensing tumor exosomal RNAs via Toll-like receptor 3 (TLR3). TLR3-deficient mice show reduced lung metastasis in the spontaneous …
Here, we demonstrate that lung epithelial cells are critical for initiating neutrophil recruitment and lung metastatic niche formation by se …
Polymorphisms in toll-like receptor 3 and 4 genes as prognostic and outcome biomarkers in melanoma patients.
Ostojic N, Radevic T, Kandolf Sekulovic L, Djordjevic B, Jaukovic L, Stepic N, Supic G. Ostojic N, et al. Melanoma Res. 2022 Oct 1;32(5):309-317. doi: 10.1097/CMR.0000000000000836. Epub 2022 Jul 19. Melanoma Res. 2022. PMID: 35855659
In the present study, we investigated whether single nucleotide polymorphisms (SNPs) in TLR3 and TLR4 genes are associated with clinicopathologic features, progression and survival of melanoma patients. ...Kaplan-Meier survival curves were compared by the log-rank test. …
In the present study, we investigated whether single nucleotide polymorphisms (SNPs) in TLR3 and TLR4 genes are associated with clini …
Gene variants in angiogenesis and lymphangiogenesis and cutaneous melanoma progression.
Park JY, Amankwah EK, Anic GM, Lin HY, Walls B, Park H, Krebs K, Madden M, Maddox K, Marzban S, Fang S, Chen W, Lee JE, Wei Q, Amos CI, Messina JL, Sondak VK, Sellers TA, Egan KM. Park JY, et al. Cancer Epidemiol Biomarkers Prev. 2013 May;22(5):827-34. doi: 10.1158/1055-9965.EPI-12-1129. Epub 2013 Mar 5. Cancer Epidemiol Biomarkers Prev. 2013. PMID: 23462921 Free PMC article.
Furthermore, in a meta-analysis, 3 additional SNPs were significantly associated with SLN metastasis (EGFR rs723526 and TLR3 rs3775292) and melanoma-specific death (TLR3 rs7668666). CONCLUSIONS: These findings suggest that genetic variation in angiogenesis and lymph …
Furthermore, in a meta-analysis, 3 additional SNPs were significantly associated with SLN metastasis (EGFR rs723526 and TLR3 rs377529 …
Temporally designed treatment of melanoma cells by ATRA and polyI: C results in enhanced chemokine and IFNbeta secretion controlled differently by TLR3 and MDA5.
Szabo A, Osman RM, Bacskai I, Kumar BV, Agod Z, Lanyi A, Gogolak P, Rajnavolgyi E. Szabo A, et al. Melanoma Res. 2012 Oct;22(5):351-61. doi: 10.1097/CMR.0b013e328357076c. Melanoma Res. 2012. PMID: 22797253
All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro. ...Silencing o …
All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and M …
IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly(I:C) partly in a TRAIL-dependent manner.
Chiba Y, Mizoguchi I, Mitobe K, Higuchi K, Nagai H, Nishigori C, Mizuguchi J, Yoshimoto T. Chiba Y, et al. PLoS One. 2013 Oct 14;8(10):e76159. doi: 10.1371/journal.pone.0076159. eCollection 2013. PLoS One. 2013. PMID: 24155891 Free PMC article.
Toll-like receptor (TLR)3 is the critical sensor of the innate immune system that serves to identify viral double-stranded RNA. TLR3 is frequently expressed by various types of malignant cells, and recent studies reported that a synthetic TLR3 agonist, polyinosinic- …
Toll-like receptor (TLR)3 is the critical sensor of the innate immune system that serves to identify viral double-stranded RNA. TLR3 …
Anti-tumor macrophages activated by ferumoxytol combined or surface-functionalized with the TLR3 agonist poly (I : C) promote melanoma regression.
Zhao J, Zhang Z, Xue Y, Wang G, Cheng Y, Pan Y, Zhao S, Hou Y. Zhao J, et al. Theranostics. 2018 Nov 29;8(22):6307-6321. doi: 10.7150/thno.29746. eCollection 2018. Theranostics. 2018. PMID: 30613299 Free PMC article.
Ferumoxytol (FMT), a clinically approved iron oxide nanoparticle, possesses anti-tumor therapeutic potential by inducing pro-inflammatory macrophage polarization. Toll-like receptor 3 (TLR3) activation also potently enhances the anti-tumor response of immune cells. Herein, …
Ferumoxytol (FMT), a clinically approved iron oxide nanoparticle, possesses anti-tumor therapeutic potential by inducing pro-inflammatory ma …
IL-24 sensitizes tumor cells to TLR3-mediated apoptosis.
Weiss R, Sachet M, Zinngrebe J, Aschacher T, Krainer M, Hegedus B, Walczak H, Bergmann M. Weiss R, et al. Cell Death Differ. 2013 Jun;20(6):823-33. doi: 10.1038/cdd.2013.15. Epub 2013 Mar 1. Cell Death Differ. 2013. PMID: 23449395 Free PMC article.
Co-administration of IL-24 decreased the presence of cFLIP in the TLR3-associated complex, converting it into an atypical, TLR3-associated death-inducing signaling complex (TLR3 DISC) that induced apoptosis by enabling caspase-8 activation at this complex. Th …
Co-administration of IL-24 decreased the presence of cFLIP in the TLR3-associated complex, converting it into an atypical, TLR3 …
The combination of ISCOMATRIX adjuvant and TLR agonists induces regression of established solid tumors in vivo.
Silva A, Mount A, Krstevska K, Pejoski D, Hardy MP, Owczarek C, Scotney P, Maraskovsky E, Baz Morelli A. Silva A, et al. J Immunol. 2015 Mar 1;194(5):2199-207. doi: 10.4049/jimmunol.1402228. Epub 2015 Feb 2. J Immunol. 2015. PMID: 25646304
In the current study, we have used B16-OVA melanoma, Panc-OVA pancreatic, and TRAMP-C1 prostate cancer mouse tumor models to test therapeutic efficacy of ISCOMATRIX vaccines combined with other immune modulators. The coadministration of an ISCOMATRIX vaccine with the TLR3 …
In the current study, we have used B16-OVA melanoma, Panc-OVA pancreatic, and TRAMP-C1 prostate cancer mouse tumor models to test therapeuti …
[What's new in dermatological research?].
Misery L. Misery L. Ann Dermatol Venereol. 2012 Dec;139 Suppl 5:S188-93. doi: 10.1016/S0151-9638(12)70133-3. Ann Dermatol Venereol. 2012. PMID: 23522705 French.
In culture, melanocytes can be dedifferentiated in melanoblasts. Sunburns are consecutive to the activation of TLR3 by UVB. ANRIL gene is involved in the polymorphism of neurofibromatosis 1 and gene RAD51B is linked to the risk of male breast cancer. ...
In culture, melanocytes can be dedifferentiated in melanoblasts. Sunburns are consecutive to the activation of TLR3 by UVB. ANRIL gen …
Association of inherited variation in Toll-like receptor genes with malignant melanoma susceptibility and survival.
Gast A, Bermejo JL, Claus R, Brandt A, Weires M, Weber A, Plass C, Sucker A, Hemminki K, Schadendorf D, Kumar R. Gast A, et al. PLoS One. 2011;6(9):e24370. doi: 10.1371/journal.pone.0024370. Epub 2011 Sep 9. PLoS One. 2011. PMID: 21931695 Free PMC article.
The relationship between genotype, disease status and survival was investigated taking into account patient and tumor characteristics, and melanoma treatment. Analysis of 7 SNPs in TLR2, 7 SNPs in TLR3 and 8 SNPs in TLR4 showed statistically significant differences in dist …
The relationship between genotype, disease status and survival was investigated taking into account patient and tumor characteristics, and m …
12 results